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KMID : 0613820080180010016
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Journal of Life Science
2008 Volume.18 No. 1 p.16 ~ p.22
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HER-2/neu Protein Expression in Canine Mammary Adenocarcinoma
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Yang Hai-Jie
Do Sun-Hee
Yuan Dong-Wei
Hong Il-Hwa
Ki Mi-Ran
Park Jin-Kyu
Ku Moon-Jung
Lee Hye-Rim
Hong Kyung-Sook
Hwang Ok-Kyung
Han Jung-Youn
Park Ho-Yong
You Sung-Eun
Jeong Kyu-Shik
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Abstract
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In this study to evaluate the involvement of EGFR, HER-2/neu and ALCAM (CD166) oncogene products in canine mammary neoplastic lesions, sections of archived paraffin-embedded samples of 49 mammary tumors were analyzed immunohistochemically using antibodies against human EGFR and HER-2/neu and ALCAM. These 49 tumors were divided into 2 groups: 22 benign (19 adenoma, 3 benign mixed tumors) and 27 malignant tumors (2 simple adenocarcinomas, 5 complex adenocarcinomas, 3 solid carcinoma, 5 sclerosing carcinoma, 8 malignant mixed tumors and 4 malignant myoepithelioma). As a result of immunostaining, 31.8% (7/22) of the benign tumors and 29.6% (8/27) of the malignant tumors expressed the HER-2/neu oncogene product, EGFR expression was detected in 27.3% (6/22) of benign tumors and in 22.2% (6/27) of the malignant tumors. ALCAM expression was detected in 40.9% (9/22) of benign tumors and in 7.4% (2/27) of the malignant tumors. These results suggest that some of the biological and morphological characteristics of the tumor are associated with canine mammary gland tumors, as also reported for human breast cancer, the possibility of using anti-HER-2/neu antibodies in the treatment of canine mammary tumors.
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KEYWORD
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Human epidermal growth factor receptor (HER-2/neu), epidermal growth factor receptor (EGFR), activated leukocyte cell adhesion molecule (ALCAM), canine, mammary, adenocarcinoma
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